A field experiment was conducted in Piedmont plain soil of East Siang of Arunachal, India to predict the responses of rice ( Oryza sativa) to different levels of boron (B) andzinc (Zn) application. The result showed significance increase in grain and straw yield due to B fertilization. The highest yield response to the tune of 39.25 q/ha grain and 41.25 q/ha straw was recorded with 15 kg level of borax per hectare. Percent increase of grain and straw yield due to 15 kg borax alone over control was found to be 24.52 % and 17.78 % respectively. The soil also showed positive response to different levels of Zn fertilization but maximum response was observed upto 20 kg ZnSO4/ha. Boron and Zn interacted synergistically to boost yield of rice crop resulting in additional yield of 7.1 q/ha of grain and 6.28 q/ha of straw. The increased percent of grain and straw yield of rice with Zn and interaction between B × Zn were 24.87 %, 17.67 % and 47.04, 35.72 %, respectively. The boron concentration and uptake in grain and straw of rice also significantly increases with increase in level of borax upto 15 kg/ha and ZnSO4 10 kg/ha. However, a negative response was also observed in both grain and straw yield at level of 20kg/ha of borax and 30kg/ha of ZnSO4.